GreatAndromedaNebula

Hyperanalgesia is a real thing for opiates. Many argue that long term treatment actually makes pain worse overtime.

Kappa opioid agonists can cause hallucinations

You are psychologically dependent, so you would be addicted.

Can you say which receptors these are working on in the brain?

How do you differentiate those who are rationalizing their need for opioids based on pain(as addiction is very good at causing) or those who actually need them?