Ricosss

I'm with you on recommending the keto diet for health. I'm a moderator on r/ketoscience and publish research daily from pubmed.

Regarding weight control I've assembled my own theory on how our weight is managed. A central element is the type of energy available in the blood and how it is sensed by the hypothalamus which then drives all other factors. In my article I show how it explains the observed effects of fructose, hypoglycemia, 2DG, anti-depressants, melatonin, GSD3, Inuit, high protein, perinatal protein restriction, transitioning into a ketogenic diet as reported by Kevin Hall, forced overfeeding, migraine and finally T1D. That is enough diversity of situations so I suspect I'm on the right track.

https://designedbynature.design.blog/2020/05/13/hyprocico-the-theory-behind-obesity/

Now for my question :) I haven't read your latest book so it is just a guess but I doubt it references anything related to the hypothalamus. If you look on pubmed there is a plethora of publications on how the hypothalamus is in control of hunger. Why isn't this referenced in your book? (if it is, I'll buy your book ;) )

if you search on google for "pubmed hypothalamus food intake" you'll get 680,000 hits

As a general practice of good science you adjust your hypothesis when observational data shows you are wrong. If someone follows the advice and it isn't working then yes the experts are wrong. It is not that hard to understand people then search for new information as they still seek to achieve what the expert opinion falsely promises.

AMPK, SIRT1 seem to be increased while mTOR decreased on a ketogenic diet. These factors are important according to your book. Have you looked into the diet and what is your impression? Supportive for longevity?

One thing i did not see in your reflection about the future (or I missed it) is that as our living conditions improve, we tend to reduce the amount of children we have. Did you give this some thought and how that would evolve in a future where we will live much longer? A stagnating population, a full career before thinking of children... ?